منابع مشابه
Compartmentation of the Golgi complex: brefeldin-A distinguishes trans- Golgi cisternae from the trans-Golgi network
The Golgi complex is composed of at least four distinct compartments, termed the cis-, medial, and trans-Golgi cisternae and the trans-Golgi network (TGN). It has recently been reported that the organization of the Golgi complex is disrupted in cells treated with the fungal metabolite, brefeldin-A. Under these conditions, it was shown that resident enzymes of the cis-, medial, and trans-Golgi r...
متن کاملTwo New Ypt GTPases Are Required for Exit From the Yeast trans-Golgi Compartment
Small GTPases of the Ypt/rab family are involved in the regulation of vesicular transport. These GTPases apparently function during the targeting of vesicles to the acceptor compartment. Two members of the Ypt/rab family, Ypt1p and Sec4p, have been shown to regulate early and late steps of the yeast exocytic pathway, respectively. Here we tested the role of two newly identified GTPases, Ypt31p ...
متن کامل-Golgi Compartment of Osteoblastic Cells
Connexins are gap junction proteins that form aqueous channels to interconnect adjacent cells. Rat osteoblasts express connexin43 (Cx43), which forms functional gap junctions at the cell surface. We have found that ROS 17/2.8 osteosarcoma cells, UMR 106-01 osteosarcoma cells, and primary rat calvarial osteoblastic cells also express another gap junction protein, Cx46. Cx46 is a major component ...
متن کاملARF1 localizes to the golgi and the trans-golgi network.
The recruitment of coat proteins for transport vesicles (COPI-, COPII-, and clathrincoated) is mediated by the small GTPases of the ADP-ribosylation factor (ARF) family of which there are three SAR, 12 ARF, and six ARL genes in the Arabidopsis thaliana genome (Vernoud et al., 2003). These GTPases are themselves recruited by guanidine exchange factors located at the donor compartments, which con...
متن کاملEnrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment.
Acyl coenzyme A:cholesterol O-acyltransferase (ACAT) is the enzyme responsible for cholesterol esterification in macrophages leading to foam cell formation. The determination of its localization is a critical step in understanding its regulation by cholesterol. Using immunofluorescence and confocal microscopy, we previously showed that the enzyme colocalized with markers of the endoplasmic reti...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2010
ISSN: 1942-0889
DOI: 10.4161/cib.3.5.12473